Name | Parstatin (human) |
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Supplier | Tocris Bioscience |
Catalog | 2141 |
Prices | $405.00 |
Sizes | 1 mg |
Cas Number | 1065755-99-8 |
Formula | C191H330N64O53S3 |
Molecular Weight | 4467.29 |
Description | Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR 1 ) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC 50 ~ 3 μ M), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apoptotic activity in vitro . Inhibits angiogenesis and exhibits cardioprotective activity in vivo . |
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Strande JL, Widlansky ME, Tsopanoglou NE, Su J, Wang J, Hsu A, Routhu KV, Baker JE. Cardiovasc Res. 2009 Jul 15;83(2):325-34.
Zania P, Gourni D, Aplin AC, Nicosia RF, Flordellis CS, Maragoudakis ME, Tsopanoglou NE. J Pharmacol Exp Ther. 2009 Feb;328(2):378-89.