Paxilline

• Supplier: Tocris Bioscience
• Catalog: 0610
• Prices: $259.00
• Sizes: 10 mg
• Function Type: Blocker
• Cas Number: 57186-25-1
• Chemical Name: (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2'',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one
• Formula: C27H33NO4
• Molecular Weight: 435.56
• Purity: >98 %
• Description: Potent blocker of high-conductance Ca 2+ -activated K + (BK Ca , K Ca 1.1) channels. Binds to the α -subunit of BK Ca (K i = 1.9 nM for block of currents in α -subunit-expressing oocytes) and enhances binding of charybdotoxin to BK Ca channels in vascular smooth muscle. Also inhibits sarco/endoplasmic reticulum Ca 2+ -ATPase (IC 50 = 5 - 50 μ M).

Product References

Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance - Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance

Knaus HG, McManus OB, Lee SH, Schmalhofer WA, Garcia-Calvo M, Helms LM, Sanchez M, Giangiacomo K, Reuben JP, Smith AB 3rd, et al.. Biochemistry. 1994 May 17;33(19):5819-28.

Paxilline inhibition of the alpha-subunit of the high-conductance - Paxilline inhibition of the alpha-subunit of the high-conductance

Sanchez M, McManus OB. Neuropharmacology. 1996;35(7):963-8.

The mechanism of inhibition of the sarco/endoplasmic reticulum Ca2+ ATPase by - The mechanism of inhibition of the sarco/endoplasmic reticulum Ca2+ ATPase by

Bilmen JG, Wootton LL, Michelangeli F. Arch Biochem Biophys. 2002 Oct 1;406(1):55-64.