PBIT

• Supplier: Tocris Bioscience
• Catalog: 2562
• Prices: $105.00, $445.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 2514-30-9
• Chemical Name: 2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one
• Formula: C14H11NOS
• Molecular Weight: 241.31
• Purity: >98 %
• Description: JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor (IC 50 values are 3, 4.9 and 6 μ M for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Increases levels of methylated H3K4 in JARIDB1-transfected HeLa cells and MCF7 cells. Inhibits proliferation of breast cancer cell lines expressing high levels of JARIDB1.

Product References

Cell permeant polyphosphoinositide-binding peptides that block cell motility and - Cell permeant polyphosphoinositide-binding peptides that block cell motility and

Cunningham CC, Vegners R, Bucki R, Funaki M, Korde N, Hartwig JH, Stossel TP, Janmey PA. J Biol Chem. 2001 Nov 16;276(46):43390-9. Epub 2001 Aug 30.

Structural characterization and inhibitory profile of formyl peptide receptor 2 - Structural characterization and inhibitory profile of formyl peptide receptor 2

Forsman H, Andreasson E, Karlsson J, Boulay F, Rabiet MJ, Dahlgren C. J Immunol. 2012 Jul 15;189(2):629-37.