PCA 4248

• Supplier: Tocris Bioscience
• Catalog: 5564
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 123875-01-4
• Chemical Name: 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylicacidmethyl2-(phenylthio)ethylester
• Formula: C19H23NO4S
• Molecular Weight: 361.46
• Purity: >95 %
• Description: A specific PAF antagonist, more potent than the ginkolide BN-52021. Inhibits rabbit platelet aggregation with an IC 50 value of 1.05 μ M and has no significant activity on Ca 2+ channels. Active in vivo , antagonizing PAF-induced systemic hypotension and protein-plasma extravasation in rats.

Product References

Pharmacological actions of PCA 4248, a new platelet-activating factor receptor - Pharmacological actions of PCA 4248, a new platelet-activating factor receptor

Fernandez-Gallardo S, Ortega MP, Priego JG, de Casa-Juana MF, Sunkel C, Sanchez Crespo M. J Pharmacol Exp Ther. 1990 Oct;255(1):34-9.

4-Alkyl-1,4-dihydropyridines derivatives as specific PAF-acether antagonists. - 4-Alkyl-1,4-dihydropyridines derivatives as specific PAF-acether antagonists.

Sunkel CE, de Casa-Juana MF, Santos L, Gomez MM, Villarroya M, Gonzalez-Morales MA, Priego JG, Ortega MP. J Med Chem. 1990 Dec;33(12):3205-10.

1,4-Dihydropyridines, a new class of platelet-activating factor receptor - 1,4-Dihydropyridines, a new class of platelet-activating factor receptor

Ortega MP, Garcia MC, Gijon MA, de Casa-Juana MF, Priego JG, Sanchez Crespo M, Sunkel C. J Pharmacol Exp Ther. 1990 Oct;255(1):28-33.