PCI 29732

• Supplier: Tocris Bioscience
• Catalog: 0571
• Prices: $195.00, $805.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 330786-25-9
• Chemical Name: 1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• Formula: C22H21N5O
• Molecular Weight: 371.44
• Purity: >99 %
• Description: Potent BTK inhibitor (IC 50 = 0.3 nM). Blocks B cell antigen receptor (BCR)-mediated gene expression in CD20 + B cells.

Product References

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is - The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is

Honigberg LA, Smith AM, Sirisawad M, Verner E, Loury D, Chang B, Li S, Pan Z, Thamm DH, Miller RA, Buggy JJ. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80. doi:

Active site profiling reveals coupling between domains in SRC-family kinases. - Active site profiling reveals coupling between domains in SRC-family kinases.

Krishnamurty R, Brigham JL, Leonard SE, Ranjitkar P, Larson ET, Dale EJ, Merritt EA, Maly DJ. Nat Chem Biol. 2013 Jan;9(1):43-50.