PCNA I1

• Supplier: Tocris Bioscience
• Catalog: 4643
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 444930-42-1
• Chemical Name: N-(3-Methylthiophene-2-carboxylicacid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide
• Formula: C17H14N2O2S
• Molecular Weight: 310.37
• Purity: >98 %
• Description: Proliferating cell nuclear antigen (PCNA) inhibitor. Directly binds PCNA trimers (K d = 0.41 μ M), reduces chromatin-associated PCNA in cells, inhibits cell growth through induction of S and G 2 M arrest, and attenuates DNA replication in cells. Inhibits growth of a range of tumor cell lines in vitro with IC 50 values in the nanomolar to low micromolar range. Inhibits growth of prostate tumor xenografts in mice.

Product References

8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue. - 8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue.

Vliem MJ, Ponsioen B, Schwede F, Pannekoek WJ, Riedl J, Kooistra MR, Jalink K, Genieser HG, Bos JL, Rehmann H. Chembiochem. 2008 Sep 1;9(13):2052-4.

Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl - Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl

Chepurny OG, Leech CA, Kelley GG, Dzhura I, Dzhura E, Li X, Rindler MJ, Schwede F, Genieser HG, Holz GG. J Biol Chem. 2009 Apr 17;284(16):10728-36.

Isoform-specific antagonists of exchange proteins directly activated by cAMP. - Isoform-specific antagonists of exchange proteins directly activated by cAMP.

Tsalkova T, Mei FC, Li S, Chepurny OG, Leech CA, Liu T, Holz GG, Woods VL Jr, Cheng X. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8. doi:

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and - A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and

Almahariq M, Tsalkova T, Mei FC, Chen H, Zhou J, Sastry SK, Schwede F, Cheng X. Mol Pharmacol. 2013 Jan;83(1):122-8.