PD 102807

• Supplier: Tocris Bioscience
• Catalog: 4786
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 23062-91-1
• Chemical Name: 3,6a,11,14-Tetrahydro-9-methoxy-2-methyl-(12H)-isoquino[1,2-b]pyrrolo[3,2-f][1,3]benzoxazine-1-carboxylicacid,ethylester
• Formula: C23H24N2O4
• Molecular Weight: 392.45
• Purity: >98 %
• Description: Selective M 4 muscarinic receptor antagonist. IC 50 values are 91, 6559, 3441, 950 and 7412 nM for human M 4 , M 1 , M 2 , M 3 , and M 5 receptors respectively.

Product References

Identification and characterization of m4 selective muscarinic antagonists. - Identification and characterization of m4 selective muscarinic antagonists.

Augelli-Szafran CE, Jaen JC, Moreland DW, Nelson CB, Penvose-Yi JR, Schwarz RD. Bioorg Med Chem Lett. 1998 Aug 4;8(15):1991-6.

A novel muscarinic M(4) receptor antagonist provides further evidence of an - A novel muscarinic M(4) receptor antagonist provides further evidence of an

Kitaichi K, Day JC, Quirion R. Eur J Pharmacol. 1999 Oct 21;383(1):53-6.

Synthesis and pharmacology of benzoxazines as highly selective antagonists at - Synthesis and pharmacology of benzoxazines as highly selective antagonists at

Bohme TM, Augelli-Szafran CE, Hallak H, Pugsley T, Serpa K, Schwarz RD. J Med Chem. 2002 Jul 4;45(14):3094-102.