PD 118057

• Supplier: Tocris Bioscience
• Catalog: 1671
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 313674-97-4
• Chemical Name: 2-[[4-[2-(3,4-Dichlorophenyl)ethyl]phenyl]amino]benzoicacid
• Formula: C21H17Cl2NO2
• Molecular Weight: 386.27
• Purity: >99 %
• Description: Human ether-a-go-go (hERG) K V 11.1 potassium channel activator. Displays no major effect on I Na , I Ca/L , I K1 and I Ks currents. Causes resting membrane hyperpolarization and decreases action potential duration in rat myocytes in vitro .

Product References

Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers - Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers

Zhou J, Augelli-Szafran CE, Bradley JA, Chen X, Koci BJ, Volberg WA, Sun Z, Cordes JS. Mol Pharmacol. 2005 Sep;68(3):876-84. Epub 2005 Jun 23.

Pharmacological and biophysical isolation of K+ currents encoded by - Pharmacological and biophysical isolation of K+ currents encoded by

Yeung SY, Greenwood IA. Am J Physiol Cell Physiol. 2007 Jan;292(1):C468-76. Epub 2006 Jul 26.

hERG: the long and short of it. - hERG: the long and short of it.

Duff HJ. Heart Rhythm. 2008 Apr;5(4):591-2.