| Name | PD 135158 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1243 |
| Prices | $255.00, $1,045.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 130285-87-9 |
| Chemical Name | 4-[[(1R)-2-[[(2R)-3-(1H-Indol-3-yl)-2-methyl-1-oxo-2-[[[[(1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]oxy]carbonyl]amino]propyl]amino]-1-phenylethyl]amino]-4-oxobutanoicacid |
| Formula | C35H44N4O6 |
| Molecular Weight | 616.76 |
| Purity | >98 % |
| Description | Potent and selective, nonpeptide CCK 2 receptor antagonist (IC 50 values are 2.8 and 1232 nM for CCK 2 and CCK 1 respectively) that displays negligible affinity at GABA A , benzodiazepine, substance P, neurotensin, opioid, bradykinin and 5-HT 3 receptors (IC 50 > 10 μ M). Exhibits anxiolytic activity in elevated plus maze and social interaction tests and increases food intake in rats. |
| Supplier Page | Shop |
Dorre D, Smith GP. Physiol Behav. 1998 Aug;65(1):11-4.
Tsutsumi T, Akiyoshi J, Isogawa K, Kohno Y, Hikichi T, Nagayama H. Neuropeptides. 1999 Dec;33(6):483-6.