PD 144418 oxalate

• Supplier: Tocris Bioscience
• Catalog: 2608
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Cas Number: 154130-99-1
• Chemical Name: 1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridineoxalate
• Formula: C18H22N2O.C2H2O4
• Molecular Weight: 372.42
• Purity: >98 %
• Description: High affinity, selective σ 1 ligand (K i values are 0.08 and 1377 nM for σ 1 and σ 2 respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration. Also attenuates cocaine-induced hyperactivity in mice.

Product References

The pharmacology of the novel and selective sigma ligand, PD 144418. - The pharmacology of the novel and selective sigma ligand, PD 144418.

Akunne HC, Whetzel SZ, Wiley JN, Corbin AE, Ninteman FW, Tecle H, Pei Y, Pugsley TA, Heffner TG. Neuropharmacology. 1997 Jan;36(1):51-62.

Relationship between cerebral sigma-1 receptor occupancy and attenuation of - Relationship between cerebral sigma-1 receptor occupancy and attenuation of

Lever JR, Miller DK, Fergason-Cantrell EA, Green CL, Watkinson LD, Carmack TL, Lever SZ. J Pharmacol Exp Ther. 2014 Oct;351(1):153-63.