PD 146176

• Supplier: Tocris Bioscience
• Catalog: 2606
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 4079-26-9
• Chemical Name: 6,11-Dihydro[1]benzothiopyrano[4,3-b]indole
• Formula: C15H11NS
• Molecular Weight: 237.32
• Purity: >98 %
• Description: Specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (K i = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC 50 = 0.54 μ M for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo .

Product References

Attenuation of diet-induced atherosclerosis in rabbits with a highly selective - Attenuation of diet-induced atherosclerosis in rabbits with a highly selective

Sendobry SM, Cornicelli JA, Welch K, Bocan T, Tait B, Trivedi BK, Colbry N, Dyer RD, Feinmark SJ, Daugherty A. Br J Pharmacol. 1997 Apr;120(7):1199-206.

A specific 15-lipoxygenase inhibitor limits the progression and - A specific 15-lipoxygenase inhibitor limits the progression and

Bocan TM, Rosebury WS, Mueller SB, Kuchera S, Welch K, Daugherty A, Cornicelli JA. Atherosclerosis. 1998 Feb;136(2):203-16.

Enhanced 15-HPETE production during oxidant stress induces apoptosis of - Enhanced 15-HPETE production during oxidant stress induces apoptosis of

Sordillo LM, Weaver JA, Cao YZ, Corl C, Sylte MJ, Mullarky IK. Prostaglandins Other Lipid Mediat. 2005 May;76(1-4):19-34.