PD 150606

• Supplier: Tocris Bioscience
• Catalog: 2850
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 179528-45-1
• Chemical Name: (Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoicacid
• Formula: C9H7IO2S
• Molecular Weight: 306.12
• Purity: >95 %
• Description: Selective, cell-permeable non-peptide calpain inhibitor (K i values for ν and m-calpains are 0.21 and 0.37 μ M respectively). Targets the calcium binding sites of calpain. Demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate.

Product References

An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable - An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable

Wang KK, Nath R, Posner A, Raser KJ, Buroker-Kilgore M, Hajimohammadreza I, Probert A W Jr, Marcoux FW, Ye Q, Takano E, Hatanaka M, Maki M, Caner H, Collins JL, Fergus A, Lee KS, Lunney EA, Hays SJ, Yuen P. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92.

Calpains mediate calcium and chloride influx during the late phase of cell - Calpains mediate calcium and chloride influx during the late phase of cell

Waters SL, Sarang SS, Wang KK, Schnellmann RG. J Pharmacol Exp Ther. 1997 Dec;283(3):1177-84.

Calpain and calpastatin regulate neutrophil apoptosis. - Calpain and calpastatin regulate neutrophil apoptosis.

Squier MK, Sehnert AJ, Sellins KS, Malkinson AM, Takano E, Cohen JJ. J Cell Physiol. 1999 Mar;178(3):311-9.