PD 153035 hydrochloride

Name PD 153035 hydrochloride
Supplier Tocris Bioscience
Catalog 1269
Prices $139.00, $585.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 183322-45-4
Chemical Name 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazolinehydrochloride
Formula C16H14BrN3O2.HCl
Molecular Weight 396.67
Description An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC 50 of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.
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Product References

A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. - A specific inhibitor of the epidermal growth factor receptor tyrosine kinase.

Fry DW, Kraker AJ, McMichael A, Ambroso LA, Nelson JM, Leopold WR, Connors RW, Bridges AJ. Science. 1994 Aug 19;265(5175):1093-5.

Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship - Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship

Bridges AJ, Zhou H, Cody DR, Rewcastle GW, McMichael A, Showalter HD, Fry DW, Kraker AJ, Denny WA. J Med Chem. 1996 Jan 5;39(1):267-76.

PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor - PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor

Bos M, Mendelsohn J, Kim YM, Albanell J, Fry DW, Baselga J. Clin Cancer Res. 1997 Nov;3(11):2099-106.