PD 158780

• Supplier: Tocris Bioscience
• Catalog: 1037
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 171179-06-9
• Chemical Name: N4-(3-Bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine
• Formula: C14H12BrN5
• Molecular Weight: 330.18
• Purity: >99 %
• Description: Potent inhibitor of ErbB receptor family tyrosine kinases (IC 50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively) that does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G 1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells.

Product References

Biochemical and antiproliferative properties of - Biochemical and antiproliferative properties of

Fry DW, Nelson JM, Slintak V, Keller PR, Rewcastle GW, Denny WA, Zhou H, Bridges AJ. Biochem Pharmacol. 1997 Oct 15;54(8):877-87.

Growth inhibition of nasopharyngeal carcinoma cells by EGF receptor tyrosine - Growth inhibition of nasopharyngeal carcinoma cells by EGF receptor tyrosine

Sun Y, Fry DW, Vincent P, Nelson JM, Elliott W, Leopold WR. Anticancer Res. 1999 Mar-Apr;19(2A):919-24.

G1 cell cycle arrest due to the inhibition of erbB family receptor tyrosine - G1 cell cycle arrest due to the inhibition of erbB family receptor tyrosine

Gonzales AJ, Fry DW. Exp Cell Res. 2005 Feb 1;303(1):56-67.