PD 161570

• Supplier: Tocris Bioscience
• Catalog: 2200
• Prices: $235.00, $965.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 192705-80-9
• Chemical Name: N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
• Formula: C26H35Cl2N7O
• Molecular Weight: 532.51
• Purity: >98 %
• Description: Selective FGFR inhibitor (IC 50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). Inhibits FGFR receptor phosphorylation (IC 50 = 622 nM) and growth of A121 cells in vitro .

Product References

Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine - Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine

Hamby JM, Connolly CJ, Schroeder MC, Winters RT, Showalter HD, Panek RL, Major TC, Olsewski B, Ryan MJ, Dahring T, Lu GH, Keiser J, Amar A, Shen C, Kraker AJ, Slintak V, Nelson JM, Fry DW, Bradford L, Hallak H, Doherty AM. J Med Chem. 1997 Jul 18;40(15):2296-303.

Inhibition of FGF-1 receptor tyrosine kinase activity by PD 161570, a new - Inhibition of FGF-1 receptor tyrosine kinase activity by PD 161570, a new

Batley BL, Doherty AM, Hamby JM, Lu GH, Keller P, Dahring TK, Hwang O, Crickard K, Panek RL. Life Sci. 1998;62(2):143-50.