PD 166285 dihydrochloride

Name PD 166285 dihydrochloride
Supplier Tocris Bioscience
Catalog 3724
Prices $105.00, $225.00
Sizes 1 mg, 10 mg
Function Type Inhibitor
Cas Number 212391-63-4
Chemical Name 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-onedihydrochloride
Formula C26H27Cl2N5O2.2HCl
Molecular Weight 585.35
Purity >99 %
Description Potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β (PDGFR β ) (IC 50 values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G 2 checkpoint.
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Product References

In vitro pharmacological characterization of PD 166285, a new nanomolar potent - In vitro pharmacological characterization of PD 166285, a new nanomolar potent

Panek RL, Lu GH, Klutchko SR, Batley BL, Dahring TK, Hamby JM, Hallak H, Doherty AM, Keiser JA. J Pharmacol Exp Ther. 1997 Dec;283(3):1433-44.

Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint - Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint

Wang Y, Li J, Booher RN, Kraker A, Lawrence T, Leopold WR, Sun Y. Cancer Res. 2001 Nov 15;61(22):8211-7.

Cell cycle regulation by the Wee1 inhibitor PD0166285, pyrido [2,3-d] pyimidine, - Cell cycle regulation by the Wee1 inhibitor PD0166285, pyrido [2,3-d] pyimidine,

Hashimoto O, Shinkawa M, Torimura T, Nakamura T, Selvendiran K, Sakamoto M, Koga H, Ueno T, Sata M. BMC Cancer. 2006 Dec 19;6:292.