PD 166793

Name PD 166793
Supplier Tocris Bioscience
Catalog 3785
Prices $139.00, $579.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 199850-67-4
Chemical Name N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine
Formula C17H18BrNO4S
Molecular Weight 412.3
Purity >99 %
Description Broad spectrum MMP inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC 50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.
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Product References

Structure-activity relationships and pharmacokinetic analysis for a series of - Structure-activity relationships and pharmacokinetic analysis for a series of

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Matrix metalloproteinase inhibition attenuates left ventricular remodeling and - Matrix metalloproteinase inhibition attenuates left ventricular remodeling and

Peterson JT, Hallak H, Johnson L, Li H, O'Brien PM, Sliskovic DR, Bocan TM, Coker ML, Etoh T, Spinale FG. Circulation. 2001 May 8;103(18):2303-9.

Effects of matrix metalloproteinase inhibition on ventricular remodeling due to - Effects of matrix metalloproteinase inhibition on ventricular remodeling due to

Chancey AL, Brower GL, Peterson JT, Janicki JS. Circulation. 2002 Apr 23;105(16):1983-8.