PD 168077 maleate

Name PD 168077 maleate
Supplier Tocris Bioscience
Catalog 2520
Prices $155.00, $645.00
Sizes 10 mg, 50 mg
Function Type Agonist
Cas Number 630117-19-0
Chemical Name N-(Methyl-4-(2-cyanophenyl)piperazinyl-3-methylbenzamidemaleate
Formula C20H22N4O.C4H4O4
Molecular Weight 450.49
Purity >99 %
Description A potent D 4 dopamine receptor agonist (K i = 8.7 nM) with > 400-fold selectivity over D 2 and > 300-fold selectivity versus D 3 subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centrally active in vivo .
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Product References

Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 - Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4

Glase SA, Akunne HC, Georgic LM, Heffner TG, MacKenzie RG, Manley PJ, Pugsley TA, Wise LD. J Med Chem. 1997 Jun 6;40(12):1771-2.

Topographically based search for an "Ethogram" among a series of novel D(4) - Topographically based search for an "Ethogram" among a series of novel D(4)

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Activation of dopamine D4 receptors induces synaptic translocation of - Activation of dopamine D4 receptors induces synaptic translocation of

Gu Z, Jiang Q, Yuen EY, Yan Z. Mol Pharmacol. 2006 Mar;69(3):813-22. Epub 2005 Dec 19.