PD 176252

• Supplier: Tocris Bioscience
• Catalog: 3552
• Prices: $269.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 204067-01-6
• Chemical Name: (S)-N-[[1-(5-Methoxy-2-pyridinyl)cyclohexyl]methyl]-α-methyl-α-[[[-(4-nitrophenyl)amino]carbonyl]amino-1H-indole-3-propanamide
• Formula: C32H36N6O5
• Molecular Weight: 584.67
• Purity: >98 %
• Description: Non-peptide gastrin-releasing peptide receptor (GRP-R, BB 2 ) and neuromedin B receptor (NMB-R, BB 1 ) antagonist (K i values are 0.17 and 1.0 nM for BB 1 and BB 2 respectively). Inhibits proliferation of rat C6 glioma cells (IC 50 = 2 μ M) and inhibits NCI-H1299 xenograft proliferation in nude mice (IC 50 = 5 μ M).

Product References

PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) - PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2)

Ashwood V, Brownhill V, Higginbottom M, Horwell DC, Hughes J, Lewthwaite RA, McKnight AT, Pinnock RD, Pritchard MC, Suman-Chauhan N, Webb C, Williams SC. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2589-94.

Nonpeptide neuromedin B receptor antagonists inhibit the proliferation of C6 - Nonpeptide neuromedin B receptor antagonists inhibit the proliferation of C6

Moody TW, Jensen RT, Garcia L, Leyton J. Eur J Pharmacol. 2000 Dec 8;409(2):133-42.

Nonpeptide gastrin releasing peptide receptor antagonists inhibit the - Nonpeptide gastrin releasing peptide receptor antagonists inhibit the

Moody TW, Leyton J, Garcia-Marin L, Jensen RT. Eur J Pharmacol. 2003 Aug 1;474(1):21-9.

Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, - Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368,

Schepetkin IA, Kirpotina LN, Khlebnikov AI, Jutila MA, Quinn MT. Mol Pharmacol. 2011 Jan;79(1):77-90.