Name | PD 180970 |
---|---|
Supplier | Tocris Bioscience |
Catalog | 2602 |
Prices | $225.00 |
Sizes | 10 mg |
Function Type | Inhibitor |
Cas Number | 287204-45-9 |
Chemical Name | 6-(2,6-Dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one |
Formula | C21H15Cl2FN4O |
Molecular Weight | 429.27 |
Purity | >98 % |
Description | ATP-competitive inhibitor of p210 bcr/abl tyrosine kinase; selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells. Inhibits in vivo tyrosine phosphorylation of Gab2, CrkL and p210 bcr/abl (IC 50 values are 80, 80 and 170 nM respectively). Potently inhibits p210 bcr/abl autophosphorylation in vitro (IC 50 = 5 nM). Also potently inhibits c-Src and KIT (IC 50 values are 0.8 and 50 nM, respectively). |
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Dorsey JF, Jove R, Kraker AJ, Wu J. Cancer Res. 2000 Jun 15;60(12):3127-31.
La Rosee P, Corbin AS, Stoffregen EP, Deininger MW, Druker BJ. Cancer Res. 2002 Dec 15;62(24):7149-53.
Corbin AS, Griswold IJ, La Rosee P, Yee KW, Heinrich MC, Reimer CL, Druker BJ, Deininger MW. Blood. 2004 Dec 1;104(12):3754-7. Epub 2004 Aug 10.