PD 180970

Name PD 180970
Supplier Tocris Bioscience
Catalog 2602
Prices $225.00
Sizes 10 mg
Function Type Inhibitor
Cas Number 287204-45-9
Chemical Name 6-(2,6-Dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one
Formula C21H15Cl2FN4O
Molecular Weight 429.27
Purity >98 %
Description ATP-competitive inhibitor of p210 bcr/abl tyrosine kinase; selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells. Inhibits in vivo tyrosine phosphorylation of Gab2, CrkL and p210 bcr/abl (IC 50 values are 80, 80 and 170 nM respectively). Potently inhibits p210 bcr/abl autophosphorylation in vitro (IC 50 = 5 nM). Also potently inhibits c-Src and KIT (IC 50 values are 0.8 and 50 nM, respectively).
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