PD 184352

• Supplier: Tocris Bioscience
• Catalog: 4965
• Prices: $235.00, $965.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 212631-79-3
• Chemical Name: 2-[(2-Chloro-4-iodophenyl)amino]-N-cyclopropylmethoxy)-3,4-difluorobenzamide
• Formula: C17H14ClF2IN2O2
• Molecular Weight: 478.66
• Description: Selective MEK inhibitor (K i = 300 nM in vitro ). Suppresses FGF-mediated angiogenesis in vivo and decreases VEGF expression. Enhances the therapeutic efficacy of taxol (Cat. No. 1097) in vivo . Orally active.

Product References

CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK). - CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK).

Allen LF, Sebolt-Leopold J, Meyer MB. Semin Oncol. 2003 Oct;30(5 Suppl 16):105-16.

Enhancement of the therapeutic efficacy of taxol by the mitogen-activated protein - Enhancement of the therapeutic efficacy of taxol by the mitogen-activated protein

McDaid HM, Lopez-Barcons L, Grossman A, Lia M, Keller S, Perez-Soler R, Horwitz SB. Cancer Res. 2005 Apr 1;65(7):2854-60.

BRAF mutation predicts sensitivity to MEK inhibition. - BRAF mutation predicts sensitivity to MEK inhibition.

Solit DB, Garraway LA, Pratilas CA, Sawai A, Getz G, Basso A, Ye Q, Lobo JM, She Y, Osman I, Golub TR, Sebolt-Leopold J, Sellers WR, Rosen N. Nature. 2006 Jan 19;439(7074):358-62. Epub 2005 Nov 6.