| Name | PD 198306 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4237 |
| Prices | $269.00 |
| Sizes | 10 mg |
| Function Type | Inhibitor |
| Cas Number | 212631-61-3 |
| Chemical Name | N-(Cyclopropylmethoxy)-3,4,5-trifluoro-2-[(4-iodo-2-methylphenyl)amino]-benzamide |
| Formula | C18H16F3IN2O2 |
| Molecular Weight | 476.23 |
| Purity | >98 % |
| Description | Potent inhibitor of MEK1/2. Inhibits isolated enzyme at a concentration of 8 nM and inhibits MEK activity in synovial fibroblasts at concentrations of 30 - 100 nM. Highly selective for MEK; IC 50 values are > 1, > 4, > 4 and > 10 μ M for ERK, c-Src, cdks and PI 3-kinase γ respectively. Antihyperalgesic; blocks static allodynia in the streptozocin model of neuropathic pain following i.t. administration. |
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