PD 407824

Name	PD 407824
Supplier	Tocris Bioscience
Catalog	5124
Prices	$105.00, $225.00
Sizes	1 mg, 10 mg
Function Type	Inhibitor
Cas Number	622864-54-4
Chemical Name	9-Hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
Formula	C20H12N2O3
Molecular Weight	328.32
Purity	>98 %
Description	Selective inhibitor of checkpoint kinases Chk1 and Wee1 (IC 50 values are 47 and 97 nM respectively). Displays selectivity over a range of other protein kinases; IC 50 values are 3.4, 3.75, > 5, > 50, > 50 and > 50 μ M for PKC, CDK4, other CDKs, c-Src, PDGFR and FGFR respectively.
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Product References

Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: - Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase:

Squire CJ, Dickson JM, Ivanovic I, Baker EN. Structure. 2005 Apr;13(4):541-50.

4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint - 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint

Palmer BD, Thompson AM, Booth RJ, Dobrusin EM, Kraker AJ, Lee HH, Lunney EA, Mitchell LH, Ortwine DF, Smaill JB, Swan LM, Denny WA. J Med Chem. 2006 Aug 10;49(16):4896-911.