PD 81723

• Supplier: Tocris Bioscience
• Catalog: 2694
• Prices: $139.00, $579.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 132861-87-1
• Chemical Name: (2-Amino-4,5-dimethyl-3-thienyl)-[3-(trifluoromethyl)phenyl]methanone
• Formula: C14H12F3NOS
• Molecular Weight: 299.31
• Purity: >99 %
• Description: Allosteric potentiator at the adenosine A 1 receptor; acts via agonist-dependent and -independent mechanisms. Enhances agonist affinity for, and increased t ½ of dissociation from, the receptor. Also inhibits basal and forskolin-stimulated adenylyl cyclase (AC) activity in A 1 receptors expressed in CHO cells, possibly via direct potentiation of constitutive receptor activity or by direct inhibition of AC. Active in vivo .

Product References

Structure-activity relationships for enhancement of adenosine A1 receptor binding - Structure-activity relationships for enhancement of adenosine A1 receptor binding

Bruns RF, Fergus JH, Coughenour LL, Courtland GG, Pugsley TA, Dodd JH, Tinney FJ. Mol Pharmacol. 1990 Dec;38(6):950-8.

PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the - PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the

Mizumura T, Auchampach JA, Linden J, Bruns RF, Gross GJ. Circ Res. 1996 Sep;79(3):415-23.

Agonist-independent effect of an allosteric enhancer of the A1 adenosine receptor - Agonist-independent effect of an allosteric enhancer of the A1 adenosine receptor

Kollias-Baker CA, Ruble J, Jacobson M, Harrison JK, Ozeck M, Shryock JC, Belardinelli L. J Pharmacol Exp Ther. 1997 May;281(2):761-8.

Adenosine A1 receptor-dependent and -independent effects of the allosteric - Adenosine A1 receptor-dependent and -independent effects of the allosteric

Musser B, Mudumbi RV, Liu J, Olson RD, Vestal RE. J Pharmacol Exp Ther. 1999 Feb;288(2):446-54.