PD 90780

• Supplier: Tocris Bioscience
• Catalog: 1363
• Prices: $195.00, $805.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 77422-99-2
• Chemical Name: 7-(Benzoylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylicacid
• Formula: C19H14N4O4
• Molecular Weight: 362.34
• Purity: >98 %
• Description: A nonpeptide inhibitor of NGF binding to p75 NTR (IC 50 ~ 1 μ M in CHO cells); binds NGF, not p75 NTR . Affinity maybe altered by the presence of TrkA receptors. Neuroprotective.

Product References

Differential activity of the nerve growth factor (NGF) antagonist PD90780 - Differential activity of the nerve growth factor (NGF) antagonist PD90780

Colquhoun A, Lawrance GM, Shamovsky IL, Riopelle RJ, Ross GM. J Pharmacol Exp Ther. 2004 Aug;310(2):505-11. Epub 2004 Mar 29.

Small molecule modulation of p75 neurotrophin receptor functions. - Small molecule modulation of p75 neurotrophin receptor functions.

Longo FM, Massa SM. CNS Neurol Disord Drug Targets. 2008 Feb;7(1):63-70.

Structural, biological, and pharmacological strategies for the inhibition of - Structural, biological, and pharmacological strategies for the inhibition of

Eibl JK, Strasser BC, Ross GM. Neurochem Int. 2012 Dec;61(8):1266-75.