PD 98059

• Supplier: Tocris Bioscience
• Catalog: 5101
• Prices: $65.00, $139.00, $585.00
• Sizes: 1 mg, 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 167869-21-8
• Chemical Name: 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
• Formula: C16H13NO3
• Molecular Weight: 267.28
• Purity: >98 %
• Description: Inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC 50 = 2-7 μ M). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G 1 arrest by blocking p53-dependent p21 induction. Enhances embryonic stem cell self-renewal. Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™ .

Product References

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein - PD 098059 is a specific inhibitor of the activation of mitogen-activated protein

Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR. J Biol Chem. 1995 Nov 17;270(46):27489-94.

A synthetic inhibitor of the mitogen-activated protein kinase cascade. - A synthetic inhibitor of the mitogen-activated protein kinase cascade.

Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7686-9.

Effects of mitogen-activated protein kinase kinase inhibitor PD 098059 on antigen - Effects of mitogen-activated protein kinase kinase inhibitor PD 098059 on antigen

Tsang F, Koh AH, Ting WL, Wong PT, Wong WS. Br J Pharmacol. 1998 Sep;125(1):61-8.

BMP4 supports self-renewal of embryonic stem cells by inhibiting - BMP4 supports self-renewal of embryonic stem cells by inhibiting

Qi X, Li TG, Hao J, Hu J, Wang J, Simmons H, Miura S, Mishina Y, Zhao GQ. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6027-32. Epub 2004 Apr 9.

Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic - Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic

Kojima K, Konopleva M, Samudio IJ, Ruvolo V, Andreeff M. Cancer Res. 2007 Apr 1;67(7):3210-9.