| Name | PDD 00017273 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 0298 |
| Prices | $269.00 |
| Sizes | 10 mg |
| Function Type | Inhibitor |
| Cas Number | 1945950-21-9 |
| Chemical Name | 1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide |
| Formula | C23H26N6O4S2 |
| Molecular Weight | 514.62 |
| Purity | >98 % |
| Description | Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC 50 = 26 nM). Exhibits >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. Maintains PAR chains and induces DNA double-stranded breaks in cells following DNA damage. Decreases colony formation of ZR-75-1 BRCA1 WT cells. Cell permeable. |
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