| Name | Penitrem A |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3045 |
| Prices | $105.00 |
| Sizes | 1 mg |
| Function Type | Blocker |
| Cas Number | 12627-35-9 |
| Chemical Name | 2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol |
| Formula | C37H44ClNO6 |
| Molecular Weight | 634.2 |
| Purity | >98 % |
| Description | Potent and selective blocker of BK Ca (K Ca 1.1) channels (IC 50 values are 6.4 and 64.4 nM for BK Ca channels containing α subunits only, and those containing α and β 1 respectively). Displays no effect on native delayed rectifier K + and K ATP currents, or cloned K V 1.5 channels. Blocks BK Ca channels in both inside-out and cell-attached patches. Shown to enhance smooth muscle contraction in vitro and increase total peripheral resistance in vivo . |
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Knaus HG, McManus OB, Lee SH, Schmalhofer WA, Garcia-Calvo M, Helms LM, Sanchez M, Giangiacomo K, Reuben JP, Smith AB 3rd, et al.. Biochemistry. 1994 May 17;33(19):5819-28.
Asano S, Bratz IN, Berwick ZC, Fancher IS, Tune JD, Dick GM. J Pharmacol Exp Ther. 2012 Aug;342(2):453-60.