PEP 005

• Supplier: Tocris Bioscience
• Catalog: 2687
• Prices: $199.00
• Sizes: 1 mg
• Function Type: Activator
• Cas Number: 75567-37-2
• Chemical Name: (2Z)-2-Methyl-2-butenoicacid(1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-ylester
• Formula: C25H34O6
• Molecular Weight: 430.53
• Purity: >98 %
• Description: Activator of protein kinase C (PKC). Exhibits antileukemic activity; induces nuclear translocation of PKC δ , and induces apoptosis in acute myeloid leukemia (AML) cell lines and primary AML blast cells. Also displays antiproliferative effects and induces apoptosis in Colo205 cells. Reactivates latent HIV in cell culture. Also acts as a substrate for multidrug transporter.

Product References

Characterization of the interaction of ingenol 3-angelate with protein kinase C. - Characterization of the interaction of ingenol 3-angelate with protein kinase C.

Kedei N, Lundberg DJ, Toth A, Welburn P, Garfield SH, Blumberg PM. Cancer Res. 2004 May 1;64(9):3243-55.

PEP005, a selective small-molecule activator of protein kinase C, has potent - PEP005, a selective small-molecule activator of protein kinase C, has potent

Hampson P, Chahal H, Khanim F, Hayden R, Mulder A, Assi LK, Bunce CM, Lord JM. Blood. 2005 Aug 15;106(4):1362-8. Epub 2005 Apr 21.

Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC - Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC

Benhadji KA, Serova M, Ghoul A, Cvitkovic E, Le Tourneau C, Ogbourne SM, Lokiec F, Calvo F, Hammel P, Faivre S, Raymond E. Br J Cancer. 2008 Dec 2;99(11):1808-15.

The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate - The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate

Li L, Shukla S, Lee A, Garfield SH, Maloney DJ, Ambudkar SV, Yuspa SH. Cancer Res. 2010 Jun 1;70(11):4509-19.