pep2-AVKI

• Supplier: Tocris Bioscience
• Catalog: 1601
• Prices: $319.00
• Sizes: 2 mg
• Function Type: Inhibitor
• Cas Number: 1315378-69-8
• Formula: C60H93N13O17
• Molecular Weight: 1268.47
• Description: Inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluR2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluR2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).

Product References

AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. - AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses.

Li P, Kerchner GA, Sala C, Wei F, Huettner JE, Sheng M, Zhuo M. Nat Neurosci. 1999 Nov;2(11):972-7.

PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent - PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent

Daw MI, Chittajallu R, Bortolotto ZA, Dev KK, Duprat F, Henley JM, Collingridge GL, Isaac JT. Neuron. 2000 Dec;28(3):873-86.

Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates - Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates

Kim CH, Chung HJ, Lee HK, Huganir RL. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11725-30.

NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex. - NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex.

Hanley JG, Khatri L, Hanson PI, Ziff EB. Neuron. 2002 Mar 28;34(1):53-67.