pep2-EVKI

Name pep2-EVKI
Supplier Tocris Bioscience
Catalog 1600
Prices $319.00
Sizes 2 mg
Function Type Inhibitor
Cas Number 1315378-67-6
Formula C62H95N13O19
Molecular Weight 1326.51
Description Inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluR2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluR2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).
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Product References

AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. - AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses.

Li P, Kerchner GA, Sala C, Wei F, Huettner JE, Sheng M, Zhuo M. Nat Neurosci. 1999 Nov;2(11):972-7.

PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent - PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent

Daw MI, Chittajallu R, Bortolotto ZA, Dev KK, Duprat F, Henley JM, Collingridge GL, Isaac JT. Neuron. 2000 Dec;28(3):873-86.

NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex. - NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex.

Hanley JG, Khatri L, Hanson PI, Ziff EB. Neuron. 2002 Mar 28;34(1):53-67.

Functional roles of protein interactions with AMPA and kainate receptors. - Functional roles of protein interactions with AMPA and kainate receptors.

Collingridge GL, Isaac JT. Neurosci Res. 2003 Sep;47(1):3-15.