pep2m

Name pep2m
Supplier Tocris Bioscience
Catalog 1599
Prices $319.00
Sizes 2 mg
Function Type Inhibitor
Cas Number 243843-42-7
Formula C49H92N18O13S
Molecular Weight 1173.44
Description Peptide inhibitor of the interaction between the C-terminus of the GluR2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates AMPA receptor function. Reduces postsynaptic currents in CA1 neurons, AMPA-mediated currents in cultured hippocampal neurons and AMPA receptor surface expression. Control peptide pep4c (Cat. No. 1596) also available.
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Product References

NSF binding to GluR2 regulates synaptic transmission. - NSF binding to GluR2 regulates synaptic transmission.

Nishimune A, Isaac JT, Molnar E, Noel J, Nash SR, Tagaya M, Collingridge GL, Nakanishi S, Henley JM. Neuron. 1998 Jul;21(1):87-97.

Role of AMPA receptor cycling in synaptic transmission and plasticity. - Role of AMPA receptor cycling in synaptic transmission and plasticity.

Luscher C, Xia H, Beattie EC, Carroll RC, von Zastrow M, Malenka RC, Nicoll RA. Neuron. 1999 Nov;24(3):649-58.

Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 - Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2

Luthi A, Chittajallu R, Duprat F, Palmer MJ, Benke TA, Kidd FL, Henley JM, Isaac JT, Collingridge GL. Neuron. 1999 Oct;24(2):389-99.

Surface expression of AMPA receptors in hippocampal neurons is regulated by an - Surface expression of AMPA receptors in hippocampal neurons is regulated by an

Noel J, Ralph GS, Pickard L, Williams J, Molnar E, Uney JB, Collingridge GL, Henley JM. Neuron. 1999 Jun;23(2):365-76.

Functional roles of protein interactions with AMPA and kainate receptors. - Functional roles of protein interactions with AMPA and kainate receptors.

Collingridge GL, Isaac JT. Neurosci Res. 2003 Sep;47(1):3-15.