PETCM

Name PETCM
Supplier Tocris Bioscience
Catalog 3097
Prices $195.00
Sizes 50 mg
Function Type Activator
Cas Number 10129-56-3
Chemical Name α-(Trichloromethyl)-4-pyridineethanol
Formula C8H8Cl3NO
Molecular Weight 240.52
Purity >99 %
Description Caspase-3 activator. Acts via inhibition of the oncoprotein ProT, therefore stimulates apoptosome formation and subsequent caspase-3 activation in a cytochrome c-dependent manner.
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Product References

Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory - Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory

Jiang X, Kim HE, Shu H, Zhao Y, Zhang H, Kofron J, Donnelly J, Burns D, Ng SC, Rosenberg S, Wang X. Science. 2003 Jan 10;299(5604):223-6.

Direct activation of the apoptosis machinery as a mechanism to target cancer - Direct activation of the apoptosis machinery as a mechanism to target cancer

Nguyen JT, Wells JA. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7533-8. Epub 2003 Jun 13.