PF 3758309 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4191
• Prices: $105.00, $445.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Chemical Name: N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamidedihydrochloride
• Formula: C25H30N8OS.2HCl
• Molecular Weight: 563.55
• Purity: >98 %
• Description: Potent PAK4 inhibitor (IC 50 = 1.3 nM; K d = 2.7 nM). Inhibits proliferation and anchorage-independent growth of a panel of tumor cell lines in vitro . Suppresses growth of human HCT116 and A549 tumor cell xenografts in mice. Orally available.

Product References

Discovery and characterization of a highly selective FAAH inhibitor that reduces - Discovery and characterization of a highly selective FAAH inhibitor that reduces

Ahn K, Johnson DS, Mileni M, Beidler D, Long JZ, McKinney MK, Weerapana E, Sadagopan N, Liimatta M, Smith SE, Lazerwith S, Stiff C, Kamtekar S, Bhattacharya K, Zhang Y, Swaney S, Van Becelaere K, Stevens RC, Cravatt BF. Chem Biol. 2009 Apr 24;16(4):411-20.

Fatty acid amide hydrolase as a potential therapeutic target for the treatment of - Fatty acid amide hydrolase as a potential therapeutic target for the treatment of

Ahn K, Johnson DS, Cravatt BF. Expert Opin Drug Discov. 2009 Jul;4(7):763-784.