PF 429242

• Supplier: Tocris Bioscience
• Catalog: 4175
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 947303-87-9
• Chemical Name: 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide
• Formula: C25H35N3O2.2HCl
• Molecular Weight: 482.49
• Purity: >97 %
• Description: Reversible, competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC 50 = 0.175 μ M). Selective for site 1 protease against a panel of serine proteases. Inhibits rate of cholesterol synthesis in CHO cells (IC 50 = 0.53 μ M). Also displays antiviral activity. Cell permeable.

Product References

Aminopyrrolidineamide inhibitors of site-1 protease. - Aminopyrrolidineamide inhibitors of site-1 protease.

Hay BA, Abrams B, Zumbrunn AY, Valentine JJ, Warren LC, Petras SF, Shelly LD, Xia A, Varghese AH, Hawkins JL, Van Camp JA, Robbins MD, Landschulz K, Harwood HJ Jr. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4411-4. Epub 2007 Jun 10.

Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory - Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory

Hawkins JL, Robbins MD, Warren LC, Xia D, Petras SF, Valentine JJ, Varghese AH, Wang IK, Subashi TA, Shelly LD, Hay BA, Landschulz KT, Geoghegan KF, Harwood HJ Jr. J Pharmacol Exp Ther. 2008 Sep;326(3):801-8.

Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein - Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein

Urata S, Yun N, Pasquato A, Paessler S, Kunz S, de la Torre JC. J Virol. 2011 Jan;85(2):795-803.

Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a - Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a

Olmstead AD, Knecht W, Lazarov I, Dixit SB, Jean F. PLoS Pathog. 2012 Jan;8(1):e1002468.