PF 431396

• Supplier: Tocris Bioscience
• Catalog: 3354
• Prices: $245.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 717906-29-1
• Chemical Name: N-Methyl-N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide
• Formula: C22H21F3N6O3S
• Molecular Weight: 506.5
• Purity: >98 %
• Description: Dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC 50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats.

Product References

Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone - Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone

Buckbinder L, Crawford DT, Qi H, Ke HZ, Olson LM, Long KR, Bonnette PC, Baumann AP, Hambor JE, Grasser WA 3rd, Pan LC, Owen TA, Luzzio MJ, Hulford CA, Gebhard DF, Paralkar VM, Simmons HA, Kath JC, Roberts WG, Smock SL, Guzman-Perez A, Brown TA, Li M. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10619-24. Epub 2007 May 30.

Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a - Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a

Han S, Mistry A, Chang JS, Cunningham D, Griffor M, Bonnette PC, Wang H, Chrunyk BA, Aspnes GE, Walker DP, Brosius AD, Buckbinder L. J Biol Chem. 2009 May 8;284(19):13193-201.

Emerging targets in osteoporosis disease modification. - Emerging targets in osteoporosis disease modification.

Allen JG, Fotsch C, Babij P. J Med Chem. 2010 Jun 10;53(11):4332-53.