| Name | PF 4708671 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4278 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1255517-76-0 |
| Chemical Name | 2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole |
| Formula | C19H21F3N6 |
| Molecular Weight | 390.41 |
| Purity | >98 % |
| Description | Cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) (K i = 20 nM; IC 50 = 160 nM). Suppresses the S6K1-mediated phosphorylation of S6, Rictor and mTOR in response to IGF1; displays no effect on the activity of RSK and MSK in vivo . Exhibits no significant inhibition of S6K2 or other AGC kinases (e.g. Akt, PKA and ROCK) in vitro . |
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