PF 477736

Name	PF 477736
Supplier	Tocris Bioscience
Catalog	4032
Prices	$245.00, $1,005.00
Sizes	10 mg, 50 mg
Function Type	Inhibitor
Cas Number	952021-60-2
Chemical Name	(R)-α-Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]-cyclohexaneacetamide
Formula	C22H25N7O2
Molecular Weight	419.48
Purity	>99 %
Description	Selective checkpoint kinase 1 (Chk1) inhibitor (K i values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G 2 -M checkpoints; sensitizes cells to DNA damage. Enhances docetaxel (Cat. No. 4056) efficacy in tumor cells and xenografts.
Supplier Page	Shop

Product References

DNA damage detection and repair pathways--recent advances with inhibitors of - DNA damage detection and repair pathways--recent advances with inhibitors of

Ashwell S, Zabludoff S. Clin Cancer Res. 2008 Jul 1;14(13):4032-7.

Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule - Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule

Blasina A, Hallin J, Chen E, Arango ME, Kraynov E, Register J, Grant S, Ninkovic S, Chen P, Nichols T, O'Connor P, Anderes K. Mol Cancer Ther. 2008 Aug;7(8):2394-404.

PF-00477736 mediates checkpoint kinase 1 signaling pathway and potentiates - PF-00477736 mediates checkpoint kinase 1 signaling pathway and potentiates

Zhang C, Yan Z, Painter CL, Zhang Q, Chen E, Arango ME, Kuszpit K, Zasadny K, Hallin M, Hallin J, Wong A, Buckman D, Sun G, Qiu M, Anderes K, Christensen JG. Clin Cancer Res. 2009 Jul 15;15(14):4630-40.