| Name | PF 4800567 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4900 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1391052-28-0 |
| Chemical Name | 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-aminehydrochloride |
| Formula | C17H18ClN5O2.HCl |
| Molecular Weight | 396.27 |
| Purity | >99 % |
| Description | Selective casein kinase 1 ε inhibitor; displays 22-fold greater potency towards CK1 ε than CK1 δ (IC 50 values are 32 and 711 nM for CK1 ε and CK1 δ respectively). ATP competitive. Displays minimal effect on the circadian clock. |
| Supplier Page | Shop |
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Etchegaray JP, Yu EA, Indic P, Dallmann R, Weaver DR. PLoS One. 2010 Apr 22;5(4):e10303.
Meng QJ, Maywood ES, Bechtold DA, Lu WQ, Li J, Gibbs JE, Dupre SM, Chesham JE, Rajamohan F, Knafels J, Sneed B, Zawadzke LE, Ohren JF, Walton KM, Wager TT, Hastings MH, Loudon AS. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15240-5. doi: