PF 5081090

• Supplier: Tocris Bioscience
• Catalog: 4252
• Prices: $265.00
• Sizes: 10 mg
• Cas Number: 1312473-63-4
• Chemical Name: (αR)-4-(2-Fluoro-4-methoxyphenyl)-N-hydroxy-α-methyl-α-(methylsulfonyl)-2-oxo-1(2H)-pyridinebutanamide
• Formula: C18H21FN2O6S
• Molecular Weight: 412.43
• Purity: >98 %
• Description: Potent antibacterial agent which disrupts lipid bilayer synthesis through inhibition of LpxC (IC 50 = 1.1 nM in Pseudomonas aeruginosa ); effective against a range of gram negative bacteria.

Product References

Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious - Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious

Montgomery JI, Brown MF, Reilly U, Price LM, Abramite JA, Arcari J, Barham R, Che Y, Chen JM, Chung SW, Collantes EM, Desbonnet C, Doroski M, Doty J, Engtrakul JJ, Harris TM, Huband M, Knafels JD, Leach KL, Liu S, Marfat A, McAllister L, McElroy E, Menard CA, Mitton-Fry M, Mullins L, Noe MC, O'Donnell J, Oliver R, Penzien J, Plummer M, Shanmugasundaram V, Thoma C, Tomaras AP, Uccello DP, Vaz A, Wishka DG. J Med Chem. 2012 Feb 23;55(4):1662-70.