| Name | PF 543 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5262 |
| Prices | $185.00, $755.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1706522-79-3 |
| Chemical Name | (2R)-1-[[(4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanolhydrochloride |
| Formula | C27H31NO4S.HCl |
| Molecular Weight | 502.07 |
| Purity | >98 % |
| Description | Potent and selective SphK1 inhibitor (IC 50 = 2 nM; K i = 3.6 nM). Exhibits >100-fold selectivity for Sphk1 over Sphk2. Also exhibits >5,000 fold selectivity over S1P 1-5 receptors and 48 protein and lipid kinases. Attenuates proliferation and induces necrosis in human colorectal cancer cells in vitro . Suppresses HCT-116 tumor xenograft growth in mice. |
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Slack-Davis JK, Martin KH, Tilghman RW, Iwanicki M, Ung EJ, Autry C, Luzzio MJ, Cooper B, Kath JC, Roberts WG, Parsons JT. J Biol Chem. 2007 May 18;282(20):14845-52. Epub 2007 Mar 28.
Kostourou V, Lechertier T, Reynolds LE, Lees DM, Baker M, Jones DT, Tavora B, Ramjaun AR, Birdsey GM, Robinson SD, Parsons M, Randi AM, Hart IR, Hodivala-Dilke K. Nat Commun. 2013;4:2020.