PF 6274484

• Supplier: Tocris Bioscience
• Catalog: 3239
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1035638-91-5
• Chemical Name: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide
• Formula: C18H14ClFN4O2
• Molecular Weight: 372.78
• Purity: >98 %
• Description: High affinity and potent covalent EGFR kinase inhibitor (K i = 0.14 nM). Inhibits autophosphorylation of WT and mutant EGFR in tumor cells (IC 50 values are 5.8 and 6.6 nM, respectively).

Product References

An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms - An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms

Badura L, Swanson T, Adamowicz W, Adams J, Cianfrogna J, Fisher K, Holland J, Kleiman R, Nelson F, Reynolds L, St Germain K, Schaeffer E, Tate B, Sprouse J. J Pharmacol Exp Ther. 2007 Aug;322(2):730-8. Epub 2007 May 14.

A role for casein kinase 1 epsilon in the locomotor stimulant response to - A role for casein kinase 1 epsilon in the locomotor stimulant response to

Bryant CD, Graham ME, Distler MG, Munoz MB, Li D, Vezina P, Sokoloff G, Palmer AA. Psychopharmacology (Berl). 2009 May;203(4):703-11. doi:

Inhibition of casein kinase I epsilon/delta produces phase shifts in the - Inhibition of casein kinase I epsilon/delta produces phase shifts in the

Sprouse J, Reynolds L, Swanson TA, Engwall M. Psychopharmacology (Berl). 2009 Jul;204(4):735-42. doi: