PF 8380

• Supplier: Tocris Bioscience
• Catalog: 3307
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1144035-53-9
• Chemical Name: 3,5-Dichlorobenzyl-[4-[3-oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]]piperazine-1-carboxylate
• Formula: C22H21Cl2N3O5
• Molecular Weight: 478.33
• Purity: >97 %
• Description: Potent autotaxin inhibitor (IC 50 = 2.8 nM in isolated enzyme assay; 101 nM in human whole blood). Modulates lysophosphatidic acid (LPA) levels in vivo and in vitro by directly inhibiting autotaxin; reduces LPA levels both in plasma and at site of inflammation. Orally available.

Product References

A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and - A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and

Gierse J, Thorarensen A, Beltey K, Bradshaw-Pierce E, Cortes-Burgos L, Hall T, Johnston A, Murphy M, Nemirovskiy O, Ogawa S, Pegg L, Pelc M, Prinsen M, Schnute M, Wendling J, Wene S, Weinberg R, Wittwer A, Zweifel B, Masferrer J. J Pharmacol Exp Ther. 2010 Jul;334(1):310-7.

Autotaxin: its role in biology of melanoma cells and as a pharmacological target. - Autotaxin: its role in biology of melanoma cells and as a pharmacological target.

Jankowski M. Enzyme Res. 2011 Mar 8;2011:194857.