| Name | PFI 1 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4074 |
| Prices | $185.00, $755.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1403764-72-6 |
| Chemical Name | 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide |
| Formula | C16H17N3O4S |
| Molecular Weight | 347.39 |
| Purity | >98 % |
| Description | Potent BET bromodomain inhibitor; exhibits inhibitory activity at bromodomain-containing protein (BRD) 2 and BRD4 (IC 50 values are 98 and 220 nM respectively). Induces apoptosis and G 1 cell cycle arrest in BET inhibitor-sensitive cell lines (MV4;11). Also downregulates Aurora B expression in MV4;11 cells. Cell permeable. |
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