( S )-PFI 2 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4892
• Prices: $299.00
• Sizes: 10 mg
• Cas Number: 1627607-88-8
• Chemical Name: (1S)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl]1,2,3,4-tetrahydro-6-isoquinolinesulfonamidehydrochloride
• Formula: C23H25F4N3O3S.HCl
• Molecular Weight: 535.98
• Purity: >97 %
• Description: Negative control of ( R )-PFI 2 hydrochloride (Cat. No. 4892). Exhibits 500-fold lower activity in a SETD7 enzymatic assay (IC 50 = 1 μ M) compared to the active enantiomer.

Product References

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity - (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity

Barsyte-Lovejoy D, Li F, Oudhoff MJ, Tatlock JH, Dong A, Zeng H, Wu H, Freeman SA, Schapira M, Senisterra GA, Kuznetsova E, Marcellus R, Allali-Hassani A, Kennedy S, Lambert JP, Couzens AL, Aman A, Gingras AC, Al-Awar R, Fish PV, Gerstenberger BS, Roberts L, Benn CL, Grimley RL, Braam MJ, Rossi FM, Sudol M, Brown PJ, Bunnage ME, Owen DR, Zaph C, Vedadi M, Arrowsmith CH. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12853-8. doi: