| Name | PFK 15 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5576 |
| Prices | $129.00, $535.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 4382-63-2 |
| Chemical Name | 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one |
| Formula | C17H12N2O |
| Molecular Weight | 260.29 |
| Purity | >99 % |
| Description | Selective PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor (IC 50 = 207 nM). Selective for PFKFB3 over a panel of 96 other kinases. Reduces glucose uptake and induces apoptosis in H522 lung adenocarcinoma and Jurkat T cell leukemia cells. Suppresses glucose uptake and tumor growth, and inhibits lung metastasis of Lewis lung carcinoma cell xenografts in mice. |
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