PG 931

• Supplier: Tocris Bioscience
• Catalog: 4919
• Prices: $255.00
• Sizes: 1 mg
• Function Type: Agonist
• Cas Number: 667430-81-1
• Formula: C59H85N15O11
• Molecular Weight: 1180.41
• Description: Potent and selective melanocortin 4 (MC 4 ) receptor agonist (IC 50 values are 0.58 and 55 nM for human MC 4 and MC 3 receptors respectively). Produces a rapid and dose dependent restoration of cardiovascular and respiratory function in hemorrhage-shocked rats.

Product References

Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: - Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119:

Grieco P, Balse-Srinivasan P, Han G, Weinberg D, MacNeil T, Van der Ploeg LH, Hruby VJ. J Pept Res. 2003 Nov;62(5):199-206.

Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and - Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and

Giuliani D, Mioni C, Bazzani C, Zaffe D, Botticelli AR, Capolongo S, Sabba A, Galantucci M, Iannone A, Grieco P, Novellino E, Colombo G, Tomasi A, Catania A, Guarini S. Br J Pharmacol. 2007 Mar;150(5):595-603. Epub 2007 Jan 22.