| Name | PH 797804 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 0750 |
| Prices | $189.00, $765.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1358027-80-1 |
| Chemical Name | (-)-3-[3-Bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethylbenzamide |
| Formula | C22H19BrF2N2O3 |
| Molecular Weight | 477.3 |
| Purity | >98 % |
| Description | Potent and selective p38 α / β inhibitor (IC 50 values are 26 and 102 nM, respectively). Exhibits >100-fold selectivity for p38 α / β over 71 other kinases, enzymes and GPCRs, including p38 γ , p38 δ , JNK and ERK2. Inhibits LPS-induced TNF α production in U937 monocytes in vitro . Suppresses acute and chronic inflammatory responses in rat models of arthritis. Orally active. |
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Faghih R, Gopalakrishnan M, Briggs CA. J Med Chem. 2008 Feb 28;51(4):701-12.