PHA 568487

• Supplier: Tocris Bioscience
• Catalog: 3092
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 527680-57-5
• Chemical Name: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,3-dihydro-1,4-benzodioxin-6-carboxamidefumarate
• Formula: C16H20N2O3.C4H4O4
• Molecular Weight: 404.41
• Purity: >99 %
• Description: Agonist of the α 7 nicotinic acetylcholine receptor (K i values are 44 and 2800 for α 7 and 5-HT 3 respectively, IC 50 values are > 100 μ M for α 3 β 4 and α 1 β 1 δ γ respectively, and % inhibition is < 1 and 5% for α 4 β 2 and hERG respectively). Orally active and brain penetrant.

Product References

Design, synthesis, structure-activity relationship, and in vivo activity of - Design, synthesis, structure-activity relationship, and in vivo activity of

Walker DP, Wishka DG, Piotrowski DW, Jia S, Reitz SC, Yates KM, Myers JK, Vetman TN, Margolis BJ, Jacobsen EJ, Acker BA, Groppi VE, Wolfe ML, Thornburgh BA, Tinholt PM, Cortes-Burgos LA, Walters RR, Hester MR, Seest EP, Dolak LA, Han F, Olson BA, Fitzgerald L, Staton BA, Raub TJ, Hajos M, Hoffmann WE, Li KS, Higdon NR, Wall TM, Hurst RS, Wong EH, Rogers BN. Bioorg Med Chem. 2006 Dec 15;14(24):8219-48. Epub 2006 Oct 2.