| Name | PHA 767491 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2693 |
| Prices | $139.00, $585.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 942425-68-5 |
| Chemical Name | 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-onehydrochloride |
| Formula | C12H11N3O.HCl |
| Molecular Weight | 249.7 |
| Purity | >99 % |
| Description | Potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC 50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. Inhibits cell proliferation in a variety of human cell lines (IC 50 ~ 0.86 - 5.87 μ M) and induces apoptosis in a p53-independent manner in vivo . Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK2) (IC 50 = 171 nM). |
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